As you all might recall few years ago.....biologist has already map the human Genome.
"The first phase of the ambitious international effort to determine the entire sequence of the human chromosome set is virtually complete. Human Genome Project scientists plan to finish the human sequence by 2003, along with a database of the most common sequence variations that distinguish one person from another"
But most of you do not understand how that is impact to future treatment of cancer. Actually i believe Cancer treatment is already inplaced but unfornately the medical community are totally unprepared......and if you are doctors now you are probably unprepared because they do not know how to read Genetics code.
Here is basically what can be done with today Genome biotechnology....particularly on area of Breast Cancer.
There are basically instrument that would be able to map your individual Genome sequencing and determine the area of Gene mutation on your body that causes Cancer.
The same machine would than map the Gene of the Cancer cell. Than BioChem can synthesis a Chemo Therapy for your Gene to shrink the Cancer grow.
Coool.........!!!!
articles in 2008.....
The SOLiD System is an end-to-end genomic analysis solution comprised of a sequencing unit, a computing cluster, and data storage. The platform is based on sequencing by oligonucleotide ligation and detection.
Professor of Physiology and Reproduction at the University of Cambridge, used the SOLiD System to determine messenger RNA (mRNA) expression profiles in mouse oocytes - immature egg cells - during early differentiation. Being able to generate comprehensive profiles of gene activity from single stem cells is expected to reveal clues about molecular variation between genetically identical stem cells and the underlying molecular mechanisms that trigger pluripotent stem cells to differentiate into specific cell types, including cancer cells. Such detailed characterizations of stem cell behavior will give researchers a better understanding of how these cells can be used in regenerative therapies for damaged cells and organs.
Originally posted by Arapahoe:As you all might recall few years ago.....biologist has already map the human Genome.
"The first phase of the ambitious international effort to determine the entire sequence of the human chromosome set is virtually complete. Human Genome Project scientists plan to finish the human sequence by 2003, along with a database of the most common sequence variations that distinguish one person from another"
But most of you do not understand how that is impact to future treatment of cancer. Actually i believe Cancer treatment is already inplaced but unfornately the medical community are totally unprepared......and if you are doctors now you are probably unprepared because they do not know how to read Genetics code.
Here is basically what can be done with today Genome biotechnology....particularly on area of Breast Cancer.
There are basically instrument that would be able to map your individual Genome sequencing and determine the area of Gene mutation on your body that causes Cancer.
The same machine would than map the Gene of the Cancer cell. Than BioChem can synthesis a Chemo Therapy for your Gene to shrink the Cancer grow.
Coool.........!!!!
You knowledge in this is at the basic level dude.
Finally I saw a post that is in my field.
In order to maximize the use of Human Genome Project to benefit humans, we need Structural Biologist.
Indeed, this project gives us an idea of our whole genome. Remember that each an everyone of us is unique, we have different genes but 99.9% of us have the same genes. It is the very little difference in us that made us unique. Our characteristic, physical and psysiological features are all different from one another.
Cancers (in general), are arise not based on the work of a single gene. It is a combination of factors that lead to the development of tumours. There may be multiple number of genes controlling the growth and development of tumour. When people say "breast cancer" gene, they do not literally refer to a gene that cause breast cancer. The vague term is only referring to a combination of genetic factors that contributes to the development of cancer.
If you are in the study of Biology, you should understand your Central Dogma of Molecular Biology, which first and foremost states that Genes product (protein) undergo various splicing and modification process. We only have a hand full of genes, but we are able to come up with tens of thousands of proteins.
It is no doubt that the root cause of cancer is highly due to mutation of genes, which results in a total/partial loss of gene function (i.e. proteins structure modification). By understanding our genome, it gives us the ability to read genes and be able to tell which type of mutation occured in the gene. Based on today's accuracy in Full Genome Sequencing, we are still far from the "Medicine of Tomorrow" or "personalize drugs".
In the treatment of cancer, you may use morder cancer treatment method which includes but not limited to chemotherapy. There are alternative methods which were reported effective against certain types of cancer. I wish to highlight to you that chemotherapy is outdated in today's morden medicine, but remained as a popular choice in cancer treatment.
Although I am not specifically into Genome Biotechnology, but I can tell that the outlined method seems to vague and without depth. As I am in the field of studies of Biomedical Science (specialization in Structural Biology, Genomics, Proteomics, and Cell Cycle and Oncology), I can tell you that there is much more going on than "shrinking the cancer grow".
Cancer is cause by the uncontrollable cell division that is without any regulations. There is no way that you can "shrink a cancer grow" because the cell division is not regulated. However, you can remove the cancerous cells by the means of surgical or medicine.
With regards to how Human Genome Project can benefit the treatment of Cancer, below are my views:
1) HGP can help to identify genetic mutations in the genome of human by comparing with a database of a population (which we do not have).
2) HGP can lead to the development of "personalize drugs" which is very specific and unique to yourself only. [Do read up on haplotypes] This can help to develop drugs that can treat the root problem of the cause of your cancer.
3) A team consisting of Structural Biologist, Molecular Biologist, Oncology Pharmacist, Geneticist can work together to create a brand-new drug that is able to cure cancers by focucing on the molecular root problem.
Best Regards,
Chin Seng
Homework Forum Moderator.
We are still a long way to go.
The debate on the risks developing pharmaceutical drugs to alter the genome versus the risks of not doing so. Is all great that we mapped our genome, but when does understanding stop and the alteration begins ?
While I may not be a biologist or a doctor, I dont see much alternative treatments being focused on, but primarily mostly focused on diferrent types of medication for chemo. And I often wonder, being a giant pharmaceutical body and all, are the medications themselves subject to scrutiny for better treatment of humans both destructive and non-destructive or are they just profit driven, like most.. no wait... all companies.
Like rat poisons as heart attack medications. lol
Anyways , hopefully, eventually... your option 3 becomes a reality. For personalised drugs, there was a debate on it, but I missed out on attending it. It was regarting ethical and political ramifications of drugs like that. But thats another story altogether.
Originally posted by BadzMaro:We are still a long way to go.
The debate on the risks developing pharmaceutical drugs to alter the genome versus the risks of not doing so. Is all great that we mapped our genome, but when does understanding stop and the alteration begins ?
While I may not be a biologist or a doctor, I dont see much alternative treatments being focused on, but primarily mostly focused on diferrent types of medication for chemo. And I often wonder, being a giant pharmaceutical body and all, are the medications themselves subject to scrutiny for better treatment of humans both destructive and non-destructive or are they just profit driven, like most.. no wait... all companies.
Like rat poisons as heart attack medications. lol
Anyways , hopefully, eventually... your option 3 becomes a reality. For personalised drugs, there was a debate on it, but I missed out on attending it. It was regarting ethical and political ramifications of drugs like that. But thats another story altogether.
Hur......who in the pharmaceutical field piss you off.....? I think you are seeing the lapse in Time.....
Most likely the drugs on the market doctor prescribe had already been in research for the past 10 yrs and was approved for human treatment by regulators. That is to say the approach of illness and treatment was at least 10 yrs ago......see the lapse in time between "knowledge vs treatment"
The drugs that is currently doing research now would not be available till another 10 yrs or so depending on the trial phase. U got to consider the financial resources invest in these research to have wait for outcome.
Genetics mutation will happen as you grow old as Darkness mention it is a series of code that mutate.
I think as for how far Genome research is going i would say pretty far reaching that most likely would piss off political social group that are idealogy base and religious leaders.
by the way The only person in biomedical is Darkness Hacker99 . I am just a causal reader.
Originally posted by Arapahoe:Hur......who in the pharmaceutical field piss you off.....? I think you are seeing the lapse in Time.....
Most likely the drugs on the market doctor prescribe had already been in research for the past 10 yrs and was approved for human treatment by regulators. That is to say the approach of illness and treatment was at least 10 yrs ago......see the lapse in time between "knowledge vs treatment"
The drugs that is currently doing research now would not be available till another 10 yrs or so depending on the trial phase. U got to consider the financial resources invest in these research to have wait for outcome.
Genetics mutation will happen as you grow old as Darkness mention it is a series of code that mutate.
I think as for how far Genome research is going i would say pretty far reaching that most likely would piss off political social group that are idealogy base and religious leaders.
by the way The only person in biomedical is Darkness Hacker99 . I am just a causal reader.
They didnt piss me off. They just pissed of lots of cancer patients that had to go through the process like a lab rat. Not to mention cancer cured, but leaving behind a lifeless whole body.
I do not doubt knowledge vs treatment. Given that we cannot do a full observation for a century to determine whether it is safe as opposed to steam rolling the medication out now, it is exactly that steam rolling that I am more skeptical then anything else.
I am aware of the financial issues. The R&D time and all.
I am more concerned with distortions of a particular area of medical/biological science to advance it without first properly understanding it thats all. =)