Several vehicles were blown from the road by the bomb, detonated in a parked car as Mr Tueni's convoy passed.
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There have been more than a dozen blasts in Lebanon since a car bomb killed former Prime Minister Rafik Hariri in February.
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The latest attack comes hours before a report on Mr Hariri's assassination is presented to the UN Security Council.
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Veteran Lebanese politician Walid Jumblatt has accused Syria of being behind the rush-hour attack.
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Damascus has said whoever carried out the bombing intended to smear Syria just as the UN report was released.
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Vigil for Williams
Hundreds of people waited outside California's San Quentin prison for the execution of ex-gang leader Stanley "Tookie" Williams.
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Emotions were high as campaigners for and against the death penalty held their vigil.
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Ex-gang members were among those who pleaded with California Governor Arnold Schwarzenegger for clemency.
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Williams' supporters called his execution "state-sponsored murder", saying he had made amends through the anti-gang children's books he wrote in jail.
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Pro-death penalty campaigners argued Williams, convicted of four murders 24 years ago, should die by lethal injection because of his lack of remorse.
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US civil rights leader Jesse Jackson was among a number of high-profile figures to support Williams in his plea for a stay of execution.
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Rev Jackson said Williams had accepted the news that his bid had failed "with a certain strength, a certain resolve".
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Mr Schwarzenegger said Williams' insistence he was innocent and refusal to apologise or atone meant the death penalty was the only option.
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Journalists who witnessed the lethal injection said the mood in the execution chamber was sombre. Supporters of Williams and relatives of his victims watched him die.
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Lebanon tribute to Tueni
Lebanese newspaper owner and critic of Syria Gibran Tueni was killed by a car bomb on Monday. On Wednesday, hundreds of thousands of people attended his Beirut funeral.
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Mourners gathered amid posters of the assassinated publisher of the popular An-Nahar daily. He was a vocal opponent of Syrian troops in Lebanon before their pullout in April.
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Mr Tueni's daughter Nayla laid her hands on her father's coffin as it was led through the Ashrafieh area of Beirut. Many Lebanese have blamed Syria for the 48-year-old's killing.
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Mourners had held a vigil on Tuesday night outside the offices of An-Nahar, condemning the assassination.
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Mourners held candles for Mr Tueni, who had just returned to Lebanon from France. The killing has led to a surge in anti-Syrian feeling.
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The killing of Mr Tueni is the fourth assassination in Lebanon this year. In February, former Prime Minister Rafik al-Hariri was killed by a car bomb.
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Mr Tueni was killed alongside his driver, a bodyguard and another person, when the bomb blew up his armour-plated car. A general strike has been called by anti-Syrian groups.
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Day in pictures: 15 December 2005
A representative of Australia's Muslim community talks to young surfers at Cronulla Beach in Sydney, amid efforts to prevent a fresh outbreak of racial unrest in the area.
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Marchers file past fashion billboards in protest at the World Trade Organisation summit in Hong Kong.
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Pakistani cricketers celebrate the dismissal of English batsman Matt Prior at the third one-day match in Karachi.
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Mourners in Gaza City gather over the coffin of a Palestinian militant killed in an Israeli strike.