Sheff Utd v Man Utd Sheffield United's Danny Webber and Claude Davis will be given until Saturday to prove their fitness.
Michael Tonge, Leigh Bromby and Steve Kabba all look set to miss out, but Paddy Kenny should be available despite having stitches in his eyebrow.
Rob HULSE is Sheffield United's top scorer with four goals.
Manchester United skipper Gary Neville has recovered from his calf problem, while Cristiano Ronaldo has overcome his ankle injury.
Patrice Evra is likely to get the nod at left-back ahead of Gabriel Heinze.
Louis SAHA is United's leading scorer with eight goals. Saha and Wayne ROONEY are the club's top marksmen as far as Premiership goals are concerned, with five each.
Sheff Utd (from): Kenny, Bennett, Unsworth, Davis, Morgan, Short, Sommeil, Leigertwood, Kozluk, Jagielka, Gillespie, A Quinn, Hulse, Nade, Kazim-Richards, Webber, Montgomery, Law, Geary.
Man Utd (from): Van der Sar, Kuszczak, Neville, O'Shea, Brown, Ferdinand, Vidic, Evra, Heinze, Ronaldo, Fletcher, Scholes, Carrick, Giggs, Richardson, Saha, Rooney, Smith.
REFEREEMark Clattenburg (Tyne & Wear)