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Bolton defender Quinton Fortune is unlikely to face his former club after picking up a calf injury in training.
Kevin Nolan is suspended and Abdoulaye Faye (concussion), Nicolas Anelka (knee) and El-Hadji Diouf (ankle) are all rated as doubtful.
Ronaldo could return for Manchester United after recovering from the flu virus that kept him out last week.
Boss Sir Alex Ferguson is likely to change his entire team from the side that beat Crewe in the Carling Cup.
BOLTON WANDERERS against Manchester United is a top three showdown pitting the Premiership's tightest defence against the leading scorers. Victory for the hosts would see them leapfrogging the table toppers
Ivan CAMPO is Bolton's leading scorer with four goals.
MANCHESTER UNITED are chasing their eighth victory in 10 Premiership outings, and fourth on the bounce. Like Bolton, two of their last three victims have included Newcastle and Liverpool. The Red Devils 'doubled' Bolton last season and have won their last three Premiership meetings.
Louis SAHA and Ole Gunnar SOLSKJAER are United's joint leading scorers with six goals each.
Bolton boss Sam Allardyce:"We have to cope with what United will throw at us.
"We've just beaten Liverpool and if we could go to Old Trafford and win as well in such a short space of time it ould be something of a miracle for us.
"It's such a big game for us that the players will drive themselves to their very limits to try and upset one of the big boys again. "But we are proud of our defensive record and will use that as catalyst to try and maintain it."
Bolton: Jaaskelainen, Hunt, Faye, Meite, Ben Haim, Giannakopoulos, Campo, Speed, Tal, Davies, Diouf, Anelka, Walker, Pedersen, Vaz Te, Fojut, Smith, Al Habsi.
Manchester United: Van der Sar, Kuszczak, Neville, Brown, Ferdinand, Vidic, O'Shea, Silvestre, Evra, Heinz, Fletcher, Ronaldo, Scholes, Carrick, Giggs, Richardson, Saha, Rooney, Smith, Solskjaer.