Where is this product sold?
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http://www.applepoly.com/procyanidin-b-2/international.htm
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with clickable goodness now..
http://www.applepoly.com/procyanidin-b-2/international.htm
anyway, it's a hair growth product or something like that right?
supposedly, nothing has been proven to work except Rogaine and Propecia
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Who says it doesnt work. it been backed by major scientific studiesOriginally posted by the Bear:with clickable goodness now..
http://www.applepoly.com/procyanidin-b-2/international.htm
anyway, it's a hair growth product or something like that right?
supposedly, nothing has been proven to work except Rogaine and Propecia
here
http://www.applepolyphenols.com/studies/hairgrowth.htmInvestigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent.
Kamimura A, Takahashi T, Watanabe Y.
Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Ibaraki, Japan. [email protected]
Procyanidin B-2 is a polyphenol compound we have identified in apple which acts as a hair-growing factor in the murine model both in vitro and in vivo. This report describes our investigation of the effects of 1% procyanidin B-2 tonic on human hair growth after sequential use for 6 months. A double-blind clinical test involving a total of 29 subjects was performed. Nineteen men in the procyanidin B-2 group and 10 men in the placebo control group were subjected to analyses. No adverse side effects were observed in either group. The hair-growing effect was evaluated using a macrophotography technique combined with measurements of the hair diameter of clipped hairs. The increase in number of total hairs in the designated scalp area (0.5 cm square = 0.25 cm2 area) of procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 6.68 +/- 5.53 (mean +/- SD)/0.25 cm2; placebo, 0.08 +/- 4.56 (mean +/- SD)/0.25 cm2; P < 0.005, two-sample t test). The increase in number of terminal hairs, which are defined as hairs more than 60 microm in diameter, in the designated area (0.5 cm square = 0.25 cm2 area) of the procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 1.99 +/- 2.58 (mean +/- SD)/0.25 cm2; placebo, -0.82 +/- 3.40 (mean +/- SD)/0.25 cm2; P < 0.02, two-sample t test). Procyanidin B-2 therapy shows potential as a safe and promising cure for male pattern baldness.
Publication Types:
· Clinical Trial
· Randomized Controlled Trial
PMID: 11194183 [PubMed - indexed for MEDLINE] -
Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo1
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Tomoya Takahashi, Toshikazu Kamiya, Atsuhiro Hasegawa,* and Yoshiharu Yokoo
Tsukuba Research Laboratories, Kyowa Hakko Kogyo, Tsukuba, Ibaraki, Japan; * Tokyo Research Laboratories, Kyowa Hakko Kogyo, Machida, Tokyo, Japan
Reprint requests to: Dr. Tomoya Takahashi, Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., 2, Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. 1The authors disclosed conflict of interest. 2Wilson C, Walkden V, Powell S, Shaw S, Wilkinson J, Dawber R: Contact dermatitis in reaction to 2% topical minoxidil solution. J Am Acad Dermatol 24:661–662, 1991 (brief communications)
We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin. Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 µM) relative to controls (=100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 µM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins. In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% ± 21.8% (mean ± SD); procyanidin B-3, 80.9% ± 13.0%; procyanidin C-1, 78.3% ± 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.
© 1999 The Society for Investigative Dermatology -
well, good luck then
i'm balding and i don't care
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bear, balding men are sexy haha so you dont have to worryOriginally posted by the Bear:well, good luck then
i'm balding and i don't care
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muahahaahah
if that was true, quack remedies for baldness would not be a billion dollar industryOriginally posted by charlene_:bear, balding men are sexy haha so you dont have to worry -
*looks at bear's avatar*Originally posted by the Bear:well, good luck then
i'm balding and i don't care
aiiiiieeeee -
The apple thing was just found. I read it a few months ago. Not only it helps hair loss but overall health benefit . Time for Yun Nam and the other sh%ts to close shop.Originally posted by the Bear:muahahaahah
if that was true, quack remedies for baldness would not be a billion dollar industry
Wonder if this product is available here in scam and scum sillypura.I will give a call tommorrow to local pharmacies to find out. Likely they dont carry it becauseproducts of this calbre is not found here. Only scams to rob your money.
Best thing about this is that u dont need the f%cking doc prescription from National suck centre when u buy propecia or rogaine. And women cant use propecia plus Rogiane is lotion troublesome to use everyday -
well, whatever...
people who find things to be angry about will never find something they'll be able to live with
and they lose their hair even faster -
Originally posted by the Bear:well, whatever...
people who find things to be angry about will never find something they'll be able to live with
and they lose their hair even faster -
I have a mild form of male pattern baldness for a few years now and maintaining the same. Some backgrund info on propecia/rogaine and how it compares with this new apple productOriginally posted by the Bear:well, whatever...
people who find things to be angry about will never find something they'll be able to live with
and they lose their hair even faster
Propecia is an inhibitor for the causes of hair loss which is DHT. It doesnt grow much hair but helps in maintaining the remining hair u have with some regrowth. Notable side effects are present and it works differently for everyone. Some sees fantastc results while others none.Some report it stopped working for them after a xxx number of years because it only inhibits 70% of DHT. The remainign DHT builds up over the years in the body and starts to exert its effects on a smaller level if u still coninue taking it
Rogaine is a lotion designed to grow hair but not inhibit completely. basically it grows hair replacing faster that has been losing with some inhibitory response. Same case as propecia, reports of being only effective for xxx no. of years
Apple polyphenols is a natural product and works on a cellular level compared to the 2 above with no side effects except positive ones. The mechanism of it interfers with certain physiological processes which has nothing to do with DHT buildup or watever. This product is likely to boost the desired effect when taken wth propecia. The same boosted result when use propecia and rogaine together
suggested reading-
http://www.applepolyphenols.com/docs/Procyanidin-B2-unpublished.pdf -
An apple a day keeps the doctor away is very true. In this case it keeps the national suck centre away.
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most probably in the states as most supplements they carry contain substances that are banned in SG.
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heck lah
got hair..
no hair
a lot of hair
so?
_____
yr pocket got $
yr pocket no $
now dats impt...
hair?.................optional -
What do u mean? if it is FDA approved , what the local scums got to say?Originally posted by caleb_chiang:most probably in the states as most supplements they carry contain substances that are banned in SG.
FDA is the major authorithy for foods and drug safety and authencity -
and why would natural products be banned especially if it from everyday products we eat like apples?
Does not make sense yes? -
I guess u havent taken a visit to national suck centre. For a simpleprescription u need to pay a f%cking 50 bucks just to sit down and listen to the crap wearing a white coat explaining why and how u are suffering from hair or skin disease. u pay 50 bucks tolisten to info which can be easily found online. Think why s'poreans flock to JB to buy prescription meds.Originally posted by Melculo:local..scums..?
u in d wrong forum dude..
i suggest... u..
Fuck off -
Eventually u end up F%ckning yourself like how u said deep deep with the hospitals and docs getting their pockets deeper.Originally posted by Melculo:MFucking idiot
every post i'll Fuck u deeeeep deeep
MFucker -
Apple Polyphenols- Medical Research
Highlights:
Many new studies on apple polyphenols are now available online. Please check the following sections for a review of the latest posted research: allergies, skin cancer, heart disease, and cholesterol.
Research into the health benefits of apple polyphenol extracts has accelerated in recent months, and an impressive body of studies is now available.
Apple polyphenol extracts are a potent scavenger of the hydroxyl radical, the most damaging type of free radicals in your body.
One of the most exciting findings on apple polyphenol extracts is their ability to dramatically increase the activity of SOD and GP, two vital intracellular free radical scavengers.
As new research is announced, you can be notified through the AP Science news bulletin. Just sign up with your name and email address at right. -
http://www.applepoly.com/blog/?p=37
A new study out this week, showing regrowth of hair in laboratory mice with high doses of polyphenols, is important news for those battling thinning hair, balding, and unwanted hair loss.
New Health & Longevity readers are aware of the clinical research showing reversal of hair loss with topical procyanidins from apple skins. The unique Poly-GRO formula is currently the only formula available containing concentrated amounts of these specific polyphenols.
Now, researchers in California report that mice given polyphenol extracts in their drinking water had complete cessation of hair loss, and significant hair regrowth after 6 months.
his study is important because it confirms the field results of many users of Apple PolyTM capsules, who find their hair growing faster and thicker with consistent oral supplementation.
The research studies showing hair growing effects of apple procyanidins has focused entirely on topical application. This is the first study to show that oral intake of large doses of polyphenols, this time from tea, also induce hair growth.
I will be posting more results- we even have pictures and graphs from this one- very soon. You can read more details right now in this article.
If you want to stop unwanted hair loss quickly, this study is exciting. Most important: every single one of the mice given the polyphenol extract had a complete cessation of further hair loss.
Every one. -
I called local stores and they said there havent heard of such product
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Anybody seen the product in stores, please let me know....
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if u seen thisproduct , please let me know. thanks