Alumni from the King Edward VII College of Medicine/Raffles College era (1905 to 1949)
* Lee Kuan Yew - Founding Prime Minister of Singapore
* Mahathir bin Mohamad - 4th Prime Minister of Malaysia
* Goh Keng Swee - former Deputy Prime Minister of Singapore
* Toh Chin Chye - former Deputy Prime Minister of Singapore
* Tun Abdul Razak - 2nd Prime Minister of Malaysia
* Benjamin Sheares - 2nd President of Singapore
Alumni from the University of Malaya (Singapore) era (1949 to 1962)
* Sellapan Ramanathan - President of Singapore and NUS Chancellor
* Wang Gungwu - Director of the East Asian Institute at NUS
Alumni from the University of Singapore era (1962 to 1980)
* Goh Chok Tong - current Senior Minister of Singapore and former Prime Minister of Singapore
* Shunmugam Jayakumar - former Minister for Foreign Affairs of Singapore
* Yaacob Ibrahim - Minister for the Environment and Water Resources and Minister-in-charge of Muslim Affairs in Singapore.
* Kishore Mahbubani - dean of the Lee Kuan Yew School of Public Policy at NUS
* Wong Kan Seng - Deputy Prime Minister of Singapore
* Tan Choo Leng - wife of Senior Minister Goh Chok Tong and former patron of the National Kidney Foundation in Singapore
* Abdullah Tarmugi - Speaker of Parliament in Singapore and former Minister in the Singapore Government.
* Balaji Sadasivan - Neurosurgeon and Senior Minister of State for Foreign Affairs in Singapore
* Chan Heng Chee - Professor of Political Science and Singapore's Ambassador to the United States
* Chew Choon Seng - CEO of Singapore Airlines
* Ong Keng Yong - secretary-general of the Association of Southeast Asian Nations (ASEAN)
* Subhas Anandan - reputable Singapore criminal lawyer and senior consultant at Harry Elias Partnership
* Lin Hsin Hsin - reputable artist and digital media pioneer
* Choo San Goh - prominent chorographer involved with the Washington Ballet
* Arthur Yap - prominent poet and linguist
The National University of Singapore era (1980 - )
* Woon Cheong Ming Walter - former Nominiated member of Parliament and Singapore Ambassador to Belgium, The Netherlands, Luxembourg and the Holy See
* Ng Eng Hen - Minister of Manpower and Second Minister of Defence in Singapore
* K. Shanmugam- Senior Counsel and Member of Parliament in Singapore for Sembawang Group Representation Constituency
* Davinder Singh - Senior Counsel and CEO of Drew & Napier
* Vivian Balakrishnan - Minister for Community Development, Youth and Sports in Singapore.
* Sha'ari Tadin - former Senior Parliamentary Secretary and first Malay graduate PAP Member of Parliament, Singapore
* Low Thia Khiang - Secretary-General of the Workers' Party of Singapore and Member of Parliament in Singapore for Hougang constituency
* Olivia Lum - entrepreneur, founder & CEO of Hyflux Group
* Sylvia Lim - Chairman of the Workers' Party of Singapore and lecturer at Temasek Polytechnic in Singapore
* Steve Chia - secretary-general of the National Solidarity Party and former Non-Constituency Member of Parliament (2002 to 2006)
* Alex Au - independent writer who publishes articles on the internet under the moniker "Yawningbread" and prominent gay rights activist
* James Gomez - Second Assistant Secretary-General of the Workers' Party of Singapore and Programme Officer of the Political Parties Programme at the International Institute for Democracy and Electoral Assistance (IDEA)
* Jeanette Aw - Actress
* Kelvin Lim - Singer and well-known blogger
* Stella (Singaporean singer)
* Tan Cheng Han - current Dean of NUS law school
* Kaira Gong - Singer
* Chew Sin Huey - Singer
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